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學生對 西奈山伊坎医学院 提供的 大数据科学与 BD2K-LINCS 数据协调和集成中心 的評價和反饋

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23 個評分

課程概述

The Library of Integrative Network-based Cellular Signatures (LINCS) is an NIH Common Fund program. The idea is to perturb different types of human cells with many different types of perturbations such as: drugs and other small molecules; genetic manipulations such as knockdown or overexpression of single genes; manipulation of the extracellular microenvironment conditions, for example, growing cells on different surfaces, and more. These perturbations are applied to various types of human cells including induced pluripotent stem cells from patients, differentiated into various lineages such as neurons or cardiomyocytes. Then, to better understand the molecular networks that are affected by these perturbations, changes in level of many different variables are measured including: mRNAs, proteins, and metabolites, as well as cellular phenotypic changes such as changes in cell morphology. The BD2K-LINCS Data Coordination and Integration Center (DCIC) is commissioned to organize, analyze, visualize and integrate this data with other publicly available relevant resources. In this course we briefly introduce the DCIC and the various Centers that collect data for LINCS. We then cover metadata and how metadata is linked to ontologies. We then present data processing and normalization methods to clean and harmonize LINCS data. This follow discussions about how data is served as RESTful APIs. Most importantly, the course covers computational methods including: data clustering, gene-set enrichment analysis, interactive data visualization, and supervised learning. Finally, we introduce crowdsourcing/citizen-science projects where students can work together in teams to extract expression signatures from public databases and then query such collections of signatures against LINCS data for predicting small molecules as potential therapeutics....

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JS

2020年5月9日

Excellent course! Thoroughly enjoyed learning from these excellent instructors. With very little prior knowledge on the topic, the course was quite easy to follow and very well explained!

MS

2017年1月20日

A very practical courses. Very good introduction to Big Data sources and Computational Analysis tool.

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1 - 大数据科学与 BD2K-LINCS 数据协调和集成中心 的 8 個評論(共 8 個)

創建者 Tomas R

2020年2月24日

創建者 Jaspreet S P

2020年3月22日

創建者 Musalula S

2017年1月21日

創建者 Jacqulene P S S

2020年5月10日

創建者 Jose M V

2017年7月29日

創建者 Dong A

2022年10月25日

創建者 Nagasai H

2018年9月19日

創建者 Ezra L

2018年2月27日